Cargando…
REG-γ associates with and modulates the abundance of nuclear activation-induced deaminase
Activation-induced deaminase (AID) acts on the immunoglobulin loci in activated B lymphocytes to initiate antibody gene diversification. The abundance of AID in the nucleus appears tightly regulated, with most nuclear AID being either degraded or exported back to the cytoplasm. To gain insight into...
Autores principales: | Uchimura, Yasuhiro, Barton, Lance F., Rada, Cristina, Neuberger, Michael S. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
2011
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3256965/ https://www.ncbi.nlm.nih.gov/pubmed/22042974 http://dx.doi.org/10.1084/jem.20110856 |
Ejemplares similares
-
IFN-γ– and IL-10–expressing virus epitope-specific Foxp3(+) T reg cells in the central nervous system during encephalomyelitis
por: Zhao, Jingxian, et al.
Publicado: (2011) -
The Activation-induced Deaminase Functions in a Postcleavage Step of the Somatic Hypermutation Process
por: Papavasiliou, F. Nina, et al.
Publicado: (2002) -
miR-181b negatively regulates activation-induced cytidine deaminase in B cells
por: de Yébenes, Virginia G., et al.
Publicado: (2008) -
T reg–specific insulin receptor deletion prevents diet-induced and age-associated metabolic syndrome
por: Wu, Dan, et al.
Publicado: (2020) -
Selective miRNA disruption in T reg cells leads to uncontrolled autoimmunity
por: Zhou, Xuyu, et al.
Publicado: (2008)