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Register shifting of an insulin peptide–MHC complex allows diabetogenic T cells to escape thymic deletion
In nonobese diabetic (NOD) mice, two sets of autoreactive CD4(+) T cells recognize the B:9–23 segment of the insulin B chain. One set, type A, recognizes insulin presented by antigen-presenting cells (APCs). These T cells are highly deleted in the thymus. The second set, type B, does not recognize i...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3256971/ https://www.ncbi.nlm.nih.gov/pubmed/22065673 http://dx.doi.org/10.1084/jem.20111502 |