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Register shifting of an insulin peptide–MHC complex allows diabetogenic T cells to escape thymic deletion

In nonobese diabetic (NOD) mice, two sets of autoreactive CD4(+) T cells recognize the B:9–23 segment of the insulin B chain. One set, type A, recognizes insulin presented by antigen-presenting cells (APCs). These T cells are highly deleted in the thymus. The second set, type B, does not recognize i...

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Detalles Bibliográficos
Autores principales:	Mohan, James F., Petzold, Shirley J., Unanue, Emil R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2011
Materias:	Brief Definitive Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3256971/ https://www.ncbi.nlm.nih.gov/pubmed/22065673 http://dx.doi.org/10.1084/jem.20111502

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