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Dietary Lipoic Acid Influences Antioxidant Capability and Oxidative Status of Broilers
The effects of lipoic acid (LA) on the antioxidant status of broilers were investigated. Birds (1 day old) were randomly assigned to four groups and fed corn-soybean diets supplemented with 0, 100, 200, 300 mg/kg LA, respectively. The feeding program included a starter diet from 1 to 21 days of age...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Molecular Diversity Preservation International (MDPI)
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3257082/ https://www.ncbi.nlm.nih.gov/pubmed/22272085 http://dx.doi.org/10.3390/ijms12128476 |
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author | Chen, Peng Ma, Qiu-Gang Ji, Cheng Zhang, Jian-Yun Zhao, Li-Hong Zhang, Yong Jie, Yong-Ze |
author_facet | Chen, Peng Ma, Qiu-Gang Ji, Cheng Zhang, Jian-Yun Zhao, Li-Hong Zhang, Yong Jie, Yong-Ze |
author_sort | Chen, Peng |
collection | PubMed |
description | The effects of lipoic acid (LA) on the antioxidant status of broilers were investigated. Birds (1 day old) were randomly assigned to four groups and fed corn-soybean diets supplemented with 0, 100, 200, 300 mg/kg LA, respectively. The feeding program included a starter diet from 1 to 21 days of age and a grower diet from 22 to 42 days of age. Serum, liver and muscle samples were collected at 42 days of age. For antioxidant enzymes, superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activity in serum, liver and breast muscle significantly increased in chickens fed with LA. The concentration of malondiadehyde (MDA), an indicator of lipid peroxidation, was significantly lower in serum, liver and leg muscle in birds that received LA than in the control group. Treatments with LA significantly increased glutathione (GSH) content in liver and increased α-tocopherol content in leg muscle as compared to the control. These results indicate that dietary supplementation with 300 mg/kg LA may enhance antioxidant capability and depress oxidative stress in broilers. |
format | Online Article Text |
id | pubmed-3257082 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Molecular Diversity Preservation International (MDPI) |
record_format | MEDLINE/PubMed |
spelling | pubmed-32570822012-01-23 Dietary Lipoic Acid Influences Antioxidant Capability and Oxidative Status of Broilers Chen, Peng Ma, Qiu-Gang Ji, Cheng Zhang, Jian-Yun Zhao, Li-Hong Zhang, Yong Jie, Yong-Ze Int J Mol Sci Article The effects of lipoic acid (LA) on the antioxidant status of broilers were investigated. Birds (1 day old) were randomly assigned to four groups and fed corn-soybean diets supplemented with 0, 100, 200, 300 mg/kg LA, respectively. The feeding program included a starter diet from 1 to 21 days of age and a grower diet from 22 to 42 days of age. Serum, liver and muscle samples were collected at 42 days of age. For antioxidant enzymes, superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activity in serum, liver and breast muscle significantly increased in chickens fed with LA. The concentration of malondiadehyde (MDA), an indicator of lipid peroxidation, was significantly lower in serum, liver and leg muscle in birds that received LA than in the control group. Treatments with LA significantly increased glutathione (GSH) content in liver and increased α-tocopherol content in leg muscle as compared to the control. These results indicate that dietary supplementation with 300 mg/kg LA may enhance antioxidant capability and depress oxidative stress in broilers. Molecular Diversity Preservation International (MDPI) 2011-11-29 /pmc/articles/PMC3257082/ /pubmed/22272085 http://dx.doi.org/10.3390/ijms12128476 Text en © 2011 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0 This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Article Chen, Peng Ma, Qiu-Gang Ji, Cheng Zhang, Jian-Yun Zhao, Li-Hong Zhang, Yong Jie, Yong-Ze Dietary Lipoic Acid Influences Antioxidant Capability and Oxidative Status of Broilers |
title | Dietary Lipoic Acid Influences Antioxidant Capability and Oxidative Status of Broilers |
title_full | Dietary Lipoic Acid Influences Antioxidant Capability and Oxidative Status of Broilers |
title_fullStr | Dietary Lipoic Acid Influences Antioxidant Capability and Oxidative Status of Broilers |
title_full_unstemmed | Dietary Lipoic Acid Influences Antioxidant Capability and Oxidative Status of Broilers |
title_short | Dietary Lipoic Acid Influences Antioxidant Capability and Oxidative Status of Broilers |
title_sort | dietary lipoic acid influences antioxidant capability and oxidative status of broilers |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3257082/ https://www.ncbi.nlm.nih.gov/pubmed/22272085 http://dx.doi.org/10.3390/ijms12128476 |
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