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Dietary Lipoic Acid Influences Antioxidant Capability and Oxidative Status of Broilers

The effects of lipoic acid (LA) on the antioxidant status of broilers were investigated. Birds (1 day old) were randomly assigned to four groups and fed corn-soybean diets supplemented with 0, 100, 200, 300 mg/kg LA, respectively. The feeding program included a starter diet from 1 to 21 days of age...

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Autores principales: Chen, Peng, Ma, Qiu-Gang, Ji, Cheng, Zhang, Jian-Yun, Zhao, Li-Hong, Zhang, Yong, Jie, Yong-Ze
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3257082/
https://www.ncbi.nlm.nih.gov/pubmed/22272085
http://dx.doi.org/10.3390/ijms12128476
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author Chen, Peng
Ma, Qiu-Gang
Ji, Cheng
Zhang, Jian-Yun
Zhao, Li-Hong
Zhang, Yong
Jie, Yong-Ze
author_facet Chen, Peng
Ma, Qiu-Gang
Ji, Cheng
Zhang, Jian-Yun
Zhao, Li-Hong
Zhang, Yong
Jie, Yong-Ze
author_sort Chen, Peng
collection PubMed
description The effects of lipoic acid (LA) on the antioxidant status of broilers were investigated. Birds (1 day old) were randomly assigned to four groups and fed corn-soybean diets supplemented with 0, 100, 200, 300 mg/kg LA, respectively. The feeding program included a starter diet from 1 to 21 days of age and a grower diet from 22 to 42 days of age. Serum, liver and muscle samples were collected at 42 days of age. For antioxidant enzymes, superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activity in serum, liver and breast muscle significantly increased in chickens fed with LA. The concentration of malondiadehyde (MDA), an indicator of lipid peroxidation, was significantly lower in serum, liver and leg muscle in birds that received LA than in the control group. Treatments with LA significantly increased glutathione (GSH) content in liver and increased α-tocopherol content in leg muscle as compared to the control. These results indicate that dietary supplementation with 300 mg/kg LA may enhance antioxidant capability and depress oxidative stress in broilers.
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spelling pubmed-32570822012-01-23 Dietary Lipoic Acid Influences Antioxidant Capability and Oxidative Status of Broilers Chen, Peng Ma, Qiu-Gang Ji, Cheng Zhang, Jian-Yun Zhao, Li-Hong Zhang, Yong Jie, Yong-Ze Int J Mol Sci Article The effects of lipoic acid (LA) on the antioxidant status of broilers were investigated. Birds (1 day old) were randomly assigned to four groups and fed corn-soybean diets supplemented with 0, 100, 200, 300 mg/kg LA, respectively. The feeding program included a starter diet from 1 to 21 days of age and a grower diet from 22 to 42 days of age. Serum, liver and muscle samples were collected at 42 days of age. For antioxidant enzymes, superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activity in serum, liver and breast muscle significantly increased in chickens fed with LA. The concentration of malondiadehyde (MDA), an indicator of lipid peroxidation, was significantly lower in serum, liver and leg muscle in birds that received LA than in the control group. Treatments with LA significantly increased glutathione (GSH) content in liver and increased α-tocopherol content in leg muscle as compared to the control. These results indicate that dietary supplementation with 300 mg/kg LA may enhance antioxidant capability and depress oxidative stress in broilers. Molecular Diversity Preservation International (MDPI) 2011-11-29 /pmc/articles/PMC3257082/ /pubmed/22272085 http://dx.doi.org/10.3390/ijms12128476 Text en © 2011 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0 This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Chen, Peng
Ma, Qiu-Gang
Ji, Cheng
Zhang, Jian-Yun
Zhao, Li-Hong
Zhang, Yong
Jie, Yong-Ze
Dietary Lipoic Acid Influences Antioxidant Capability and Oxidative Status of Broilers
title Dietary Lipoic Acid Influences Antioxidant Capability and Oxidative Status of Broilers
title_full Dietary Lipoic Acid Influences Antioxidant Capability and Oxidative Status of Broilers
title_fullStr Dietary Lipoic Acid Influences Antioxidant Capability and Oxidative Status of Broilers
title_full_unstemmed Dietary Lipoic Acid Influences Antioxidant Capability and Oxidative Status of Broilers
title_short Dietary Lipoic Acid Influences Antioxidant Capability and Oxidative Status of Broilers
title_sort dietary lipoic acid influences antioxidant capability and oxidative status of broilers
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3257082/
https://www.ncbi.nlm.nih.gov/pubmed/22272085
http://dx.doi.org/10.3390/ijms12128476
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