Combined Pharmacophore Modeling, Docking, and 3D-QSAR Studies of PLK1 Inhibitors

Polo-like kinase 1, an important enzyme with diverse biological actions in cell mitosis, is a promising target for developing novel anticancer drugs. A combined molecular docking, structure-based pharmacophore modeling and three-dimensional quantitative structure-activity relationship (3D-QSAR) stud...

Descripción completa

Detalles Bibliográficos
Autores principales: Lu, Shuai, Liu, Hai-Chun, Chen, Ya-Dong, Yuan, Hao-Liang, Sun, Shan-Liang, Gao, Yi-Ping, Yang, Pei, Zhang, Liang, Lu, Tao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3257097/
https://www.ncbi.nlm.nih.gov/pubmed/22272100
http://dx.doi.org/10.3390/ijms12128713

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3257097/
https://www.ncbi.nlm.nih.gov/pubmed/22272100
http://dx.doi.org/10.3390/ijms12128713

Ejemplares similares