The Role of the E2F Transcription Factor Family in UV-Induced Apoptosis

The E2F transcription factor family is traditionally associated with cell cycle control. However, recent data has shown that activating E2Fs (E2F1-3a) are potent activators of apoptosis. In contrast, the recently cloned inhibitory E2Fs (E2F7 and 8) appear to antagonize E2F-induced cell death. In thi...

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Detalles Bibliográficos
Autores principales: Hazar-Rethinam, Mehlika, Endo-Munoz, Liliana, Gannon, Orla, Saunders, Nicholas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2011
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3257110/
https://www.ncbi.nlm.nih.gov/pubmed/22272113
http://dx.doi.org/10.3390/ijms12128947
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author Hazar-Rethinam, Mehlika
Endo-Munoz, Liliana
Gannon, Orla
Saunders, Nicholas
author_facet Hazar-Rethinam, Mehlika
Endo-Munoz, Liliana
Gannon, Orla
Saunders, Nicholas
author_sort Hazar-Rethinam, Mehlika
collection PubMed
description The E2F transcription factor family is traditionally associated with cell cycle control. However, recent data has shown that activating E2Fs (E2F1-3a) are potent activators of apoptosis. In contrast, the recently cloned inhibitory E2Fs (E2F7 and 8) appear to antagonize E2F-induced cell death. In this review we will discuss (i) the potential role of E2Fs in UV-induced cell death and (ii) the implications of this to the development of UV-induced cutaneous malignancies.
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spelling pubmed-32571102012-01-23 The Role of the E2F Transcription Factor Family in UV-Induced Apoptosis Hazar-Rethinam, Mehlika Endo-Munoz, Liliana Gannon, Orla Saunders, Nicholas Int J Mol Sci Review The E2F transcription factor family is traditionally associated with cell cycle control. However, recent data has shown that activating E2Fs (E2F1-3a) are potent activators of apoptosis. In contrast, the recently cloned inhibitory E2Fs (E2F7 and 8) appear to antagonize E2F-induced cell death. In this review we will discuss (i) the potential role of E2Fs in UV-induced cell death and (ii) the implications of this to the development of UV-induced cutaneous malignancies. Molecular Diversity Preservation International (MDPI) 2011-12-06 /pmc/articles/PMC3257110/ /pubmed/22272113 http://dx.doi.org/10.3390/ijms12128947 Text en © 2011 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0 This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Hazar-Rethinam, Mehlika
Endo-Munoz, Liliana
Gannon, Orla
Saunders, Nicholas
The Role of the E2F Transcription Factor Family in UV-Induced Apoptosis
title The Role of the E2F Transcription Factor Family in UV-Induced Apoptosis
title_full The Role of the E2F Transcription Factor Family in UV-Induced Apoptosis
title_fullStr The Role of the E2F Transcription Factor Family in UV-Induced Apoptosis
title_full_unstemmed The Role of the E2F Transcription Factor Family in UV-Induced Apoptosis
title_short The Role of the E2F Transcription Factor Family in UV-Induced Apoptosis
title_sort role of the e2f transcription factor family in uv-induced apoptosis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3257110/
https://www.ncbi.nlm.nih.gov/pubmed/22272113
http://dx.doi.org/10.3390/ijms12128947
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