Dynamic Structure-Based Pharmacophore Model Development: A New and Effective Addition in the Histone Deacetylase 8 (HDAC8) Inhibitor Discovery

Histone deacetylase 8 (HDAC8) is an enzyme involved in deacetylating the amino groups of terminal lysine residues, thereby repressing the transcription of various genes including tumor suppressor gene. The over expression of HDAC8 was observed in many cancers and thus inhibition of this enzyme has e...

Descripción completa

Detalles Bibliográficos
Autores principales: Thangapandian, Sundarapandian, John, Shalini, Lee, Yuno, Kim, Songmi, Lee, Keun Woo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3257139/
https://www.ncbi.nlm.nih.gov/pubmed/22272142
http://dx.doi.org/10.3390/ijms12129440

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3257139/
https://www.ncbi.nlm.nih.gov/pubmed/22272142
http://dx.doi.org/10.3390/ijms12129440

Ejemplares similares