Introducing Catastrophe-QSAR. Application on Modeling Molecular Mechanisms of Pyridinone Derivative-Type HIV Non-Nucleoside Reverse Transcriptase Inhibitors

The classical method of quantitative structure-activity relationships (QSAR) is enriched using non-linear models, as Thom’s polynomials allow either uni- or bi-variate structural parameters. In this context, catastrophe QSAR algorithms are applied to the anti-HIV-1 activity of pyridinone derivatives...

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Detalles Bibliográficos
Autores principales: Putz, Mihai V., Lazea, Marius, Putz, Ana-Maria, Duda-Seiman, Corina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3257145/
https://www.ncbi.nlm.nih.gov/pubmed/22272148
http://dx.doi.org/10.3390/ijms12129533

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3257145/
https://www.ncbi.nlm.nih.gov/pubmed/22272148
http://dx.doi.org/10.3390/ijms12129533

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