Kinase inhibitors can produce off-target effects and activate linked pathways by retroactivity

BACKGROUND: It has been shown in experimental and theoretical work that covalently modified signaling cascades naturally exhibit bidirectional signal propagation via a phenomenon known as retroactivity. An important consequence of retroactivity, which arises due to enzyme sequestration in covalently...

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Detalles Bibliográficos
Autores principales: Wynn, Michelle L, Ventura, Alejandra C, Sepulchre, Jacques A, García, Héctor J, Merajver, Sofia D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3257213/
https://www.ncbi.nlm.nih.gov/pubmed/21970676
http://dx.doi.org/10.1186/1752-0509-5-156

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3257213/
https://www.ncbi.nlm.nih.gov/pubmed/21970676
http://dx.doi.org/10.1186/1752-0509-5-156

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