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Kinase inhibitors can produce off-target effects and activate linked pathways by retroactivity
BACKGROUND: It has been shown in experimental and theoretical work that covalently modified signaling cascades naturally exhibit bidirectional signal propagation via a phenomenon known as retroactivity. An important consequence of retroactivity, which arises due to enzyme sequestration in covalently...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3257213/ https://www.ncbi.nlm.nih.gov/pubmed/21970676 http://dx.doi.org/10.1186/1752-0509-5-156 |