An RGS4-Mediated Phenotypic Switch of Bronchial Smooth Muscle Cells Promotes Fixed Airway Obstruction in Asthma

In severe asthma, bronchodilator- and steroid-insensitive airflow obstruction develops through unknown mechanisms characterized by increased lung airway smooth muscle (ASM) mass and stiffness. We explored the role of a Regulator of G-protein Signaling protein (RGS4) in the ASM hyperplasia and reduce...

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Detalles Bibliográficos
Autores principales: Damera, Gautam, Druey, Kirk M., Cooper, Philip R., Krymskaya, Vera P., Soberman, Roy J., Amrani, Yassine, Hoshi, Toshinori, Brightling, Christopher E., Panettieri, Reynold A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3257220/
https://www.ncbi.nlm.nih.gov/pubmed/22253691
http://dx.doi.org/10.1371/journal.pone.0028504

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3257220/
https://www.ncbi.nlm.nih.gov/pubmed/22253691
http://dx.doi.org/10.1371/journal.pone.0028504

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