Lipid Exchange Mechanism of the Cholesteryl Ester Transfer Protein Clarified by Atomistic and Coarse-grained Simulations

Cholesteryl ester transfer protein (CETP) transports cholesteryl esters, triglycerides, and phospholipids between different lipoprotein fractions in blood plasma. The inhibition of CETP has been shown to be a sound strategy to prevent and treat the development of coronary heart disease. We employed...

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Detalles Bibliográficos
Autores principales: Koivuniemi, Artturi, Vuorela, Timo, Kovanen, Petri T., Vattulainen, Ilpo, Hyvönen, Marja T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3257282/
https://www.ncbi.nlm.nih.gov/pubmed/22253581
http://dx.doi.org/10.1371/journal.pcbi.1002299