2-Deoxyglucose-induced toxicity is regulated by Bcl-2 family members and is enhanced by antagonizing Bcl-2 in lymphoma cell lines

Targeting altered cancer cell metabolism with the glycolysis inhibitor, 2-deoxyglucose (2DG), is a viable therapeutic strategy, but the effects of 2DG on lymphoma cells and the mechanism of action are unknown. Five T cell lymphoma lines (TCLs) and two B cell lymphoma lines (BCLs) were shown to be hi...

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Detalles Bibliográficos
Autores principales: Zagorodna, Oksana, Martin, Sean M., Rutkowski, D. Thomas, Kuwana, Tomomi, Spitz, Douglas R., Knudson, C. Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3257357/
https://www.ncbi.nlm.nih.gov/pubmed/21986940
http://dx.doi.org/10.1038/onc.2011.454

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3257357/
https://www.ncbi.nlm.nih.gov/pubmed/21986940
http://dx.doi.org/10.1038/onc.2011.454

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