Critical role for NLRP3 in necrotic death triggered by Mycobacterium tuberculosis

Induction of necrotic death in macrophages is a primary virulence determinant of Mycobacterium tuberculosis. The ESX-1 secretion system and its substrate ESAT-6 are required for M. tuberculosis to induce necrosis, but host factors that mediate the ESAT-6-promoted necrosis remain unknown. Here we rep...

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Detalles Bibliográficos
Autores principales: Wong, Ka-Wing, Jacobs Jr, William R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2011
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3257557/
https://www.ncbi.nlm.nih.gov/pubmed/21740493
http://dx.doi.org/10.1111/j.1462-5822.2011.01625.x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3257557/
https://www.ncbi.nlm.nih.gov/pubmed/21740493
http://dx.doi.org/10.1111/j.1462-5822.2011.01625.x

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