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Critical role for NLRP3 in necrotic death triggered by Mycobacterium tuberculosis
Induction of necrotic death in macrophages is a primary virulence determinant of Mycobacterium tuberculosis. The ESX-1 secretion system and its substrate ESAT-6 are required for M. tuberculosis to induce necrosis, but host factors that mediate the ESAT-6-promoted necrosis remain unknown. Here we rep...
Autores principales: | Wong, Ka-Wing, Jacobs Jr, William R |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Blackwell Publishing Ltd
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3257557/ https://www.ncbi.nlm.nih.gov/pubmed/21740493 http://dx.doi.org/10.1111/j.1462-5822.2011.01625.x |
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