Cargando…

Cortactin phosphorylation regulates cell invasion through a pH-dependent pathway

Invadopodia are invasive protrusions with proteolytic activity uniquely found in tumor cells. Cortactin phosphorylation is a key step during invadopodia maturation, regulating Nck1 binding and cofilin activity. The precise mechanism of cortactin-dependent cofilin regulation and the roles of this pat...

Descripción completa

Detalles Bibliográficos
Autores principales:	Magalhaes, Marco A. O., Larson, Daniel R., Mader, Christopher C., Bravo-Cordero, Jose Javier, Gil-Henn, Hava, Oser, Matthew, Chen, Xiaoming, Koleske, Anthony J., Condeelis, John
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2011
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3257566/ https://www.ncbi.nlm.nih.gov/pubmed/22105349 http://dx.doi.org/10.1083/jcb.201103045

Ejemplares similares

Phosphorylated cortactin recruits Vav2 guanine nucleotide exchange factor to activate Rac3 and promote invadopodial function in invasive breast cancer cells
por: Rosenberg, Brian J., et al.
Publicado: (2017)

Cortactin regulates cofilin and N-WASp activities to control the stages of invadopodium assembly and maturation
por: Oser, Matthew, et al.
Publicado: (2009)

Arg/Abl2 promotes invasion and attenuates proliferation of breast cancer in vivo
por: Gil-Henn, Hava, et al.
Publicado: (2012)

Mena(INV) dysregulates cortactin phosphorylation to promote invadopodium maturation
por: Weidmann, Maxwell D., et al.
Publicado: (2016)

Arg interacts with cortactin to promote adhesion-dependent cell edge protrusion
por: Lapetina, Stefanie, et al.
Publicado: (2009)

The repeat region of cortactin is intrinsically disordered in solution
por: Li, Xiaofeng, et al.
Publicado: (2017)

Serine phosphorylation of cortactin is required for maximal host cell invasion by Campylobacter jejuni
por: Samuelson, Derrick R, et al.
Publicado: (2013)

Cortactin in cancer cell migration and invasion
por: Yin, Miao, et al.
Publicado: (2017)

Cortactin Tyrosine Phosphorylation Promotes Its Deacetylation and Inhibits Cell Spreading
por: Meiler, Eugenia, et al.
Publicado: (2012)

FAK family kinases: The Yin and Yang of cancer cell invasiveness
por: Genna, Alessandro, et al.
Publicado: (2018)

β1 integrin regulates Arg to promote invadopodial maturation and matrix degradation
por: Beaty, Brian T., et al.
Publicado: (2013)

Cortactin function in invadopodia
por: Jeannot, Pauline, et al.
Publicado: (2017)

Oral inflammation promotes oral squamous cell carcinoma invasion
por: Goertzen, Cameron, et al.
Publicado: (2018)

Tyrosine phosphorylation of cortactin by the FAK-Src complex at focal adhesions regulates cell motility
por: Wang, Wenqi, et al.
Publicado: (2011)

Phosphorylation of cortactin by cyclin-dependent kinase 5 modulates actin bundling by the dynamin 1-cortactin ring-like complex and formation of filopodia and lamellipodia in NG108-15 glioma-derived cells
por: Abe, Tadashi, et al.
Publicado: (2018)

Phosphorylation of cortactin by cyclin-dependent kinase 5 modulates actin bundling by the dynamin 1-cortactin ring-like complex and formation of filopodia and lamellipodia in NG108-15 glioma-derived cells
por: Abe, Tadashi, et al.
Publicado: (2020)

Pro-invasive Effect of Proto-oncogene PBF Is Modulated by an Interaction with Cortactin
por: Watkins, Rachel J., et al.
Publicado: (2016)

Cortactin in Epithelial–Mesenchymal Transition
por: Ji, Rong, et al.
Publicado: (2020)

Distinct phosphorylation requirements regulate cortactin activation by Tir(EPEC )and its binding to N-WASP
por: Nieto-Pelegrin, Elvira, et al.
Publicado: (2009)

A single tyrosine phosphorylation site in cortactin is important for filopodia formation in neuronal growth cones
por: Ren, Yuan, et al.
Publicado: (2019)

Invasion and Metastasis as a Central Hallmark of Breast Cancer
por: Saha, Trishna, et al.
Publicado: (2021)

Cortactin promotes exosome secretion by controlling branched actin dynamics
por: Sinha, Seema, et al.
Publicado: (2016)

Overexpression and Tyr421-phosphorylation of cortactin is induced by three-dimensional spheroid culturing and contributes to migration and invasion of pancreatic ductal adenocarcinoma (PDAC) cells
por: Stock, Katharina, et al.
Publicado: (2019)

Pyk2 and FAK differentially regulate invadopodia formation and function in breast cancer cells
por: Genna, Alessandro, et al.
Publicado: (2018)

The Phosphorylation and Distribution of Cortactin Downstream of Integrin α9β1 Affects Cancer Cell Behaviour
por: Høye, Anette M., et al.
Publicado: (2016)

CX(3)CL1 promotes tumour cell by inducing tyrosine phosphorylation of cortactin in lung cancer
por: Fan, Mengtian, et al.
Publicado: (2020)

Cortactin and phagocytosis in isolated Sertoli cells
por: Wolski, Katja M, et al.
Publicado: (2005)

Cortactin in Lung Cell Function and Disease
por: Bandela, Mounica, et al.
Publicado: (2022)

Moesin and cortactin control actin-dependent multivesicular endosome biogenesis
por: Muriel, Olivia, et al.
Publicado: (2016)

Cortactin Phosphorylated by ERK1/2 Localizes to Sites of Dynamic Actin Regulation and Is Required for Carcinoma Lamellipodia Persistence
por: Kelley, Laura C., et al.
Publicado: (2010)

Cortactin Is Required for Efficient FAK, Src and Abl Tyrosine Kinase Activation and Phosphorylation of Helicobacter pylori CagA
por: Knorr, Jakob, et al.
Publicado: (2021)

Transgenic mice with mammary gland targeted expression of human cortactin do not develop (pre-malignant) breast tumors: studies in MMTV-cortactin and MMTV-cortactin/-cyclin D1 bitransgenic mice
por: van Rossum, Agnes GSH, et al.
Publicado: (2006)

Cortactin and Crk cooperate to trigger actin polymerization during Shigella invasion of epithelial cells
por: Bougnères, Laurence, et al.
Publicado: (2004)

High expression of PTBP1 promote invasion of colorectal cancer by alternative splicing of cortactin
por: Wang, Zhi-na, et al.
Publicado: (2017)

Role of Src and Cortactin in Pemphigus Skin Blistering
por: Kugelmann, Daniela, et al.
Publicado: (2019)

Distribution of cortactin in cerebellar Purkinje cell spines
por: Szabó, Lilla E., et al.
Publicado: (2021)

A guide to simple, direct, and quantitative in vitro binding assays
por: Lapetina, Stefanie, et al.
Publicado: (2017)

Invadopodia, a Kingdom of Non-Receptor Tyrosine Kinases
por: Saha, Trishna, et al.
Publicado: (2021)

Cofilin is a pH sensor for actin free barbed end formation: role of phosphoinositide binding
por: Frantz, Christian, et al.
Publicado: (2008)

Cortactin expression predicts poor survival in laryngeal carcinoma
por: Gibcus, J H, et al.
Publicado: (2008)

Cannot write session to /tmp/vufind_sessions/sess_4dscujubk0c3l106pkh4fcu4bm