Mus81-mediated DNA cleavage resolves replication forks stalled by topoisomerase I–DNA complexes

Deoxyribonucleic acid (DNA) topoisomerases are essential for removing the supercoiling that normally builds up ahead of replication forks. The camptothecin (CPT) Top1 (topoisomerase I) inhibitors exert their anticancer activity by reversibly trapping Top1–DNA cleavage complexes (Top1cc’s) and induci...

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Detalles Bibliográficos
Autores principales: Regairaz, Marie, Zhang, Yong-Wei, Fu, Haiqing, Agama, Keli K., Tata, Nalini, Agrawal, Surbhi, Aladjem, Mirit I., Pommier, Yves
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2011
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3257568/
https://www.ncbi.nlm.nih.gov/pubmed/22123861
http://dx.doi.org/10.1083/jcb.201104003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3257568/
https://www.ncbi.nlm.nih.gov/pubmed/22123861
http://dx.doi.org/10.1083/jcb.201104003

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