Cargando…

Mus81-mediated DNA cleavage resolves replication forks stalled by topoisomerase I–DNA complexes

Deoxyribonucleic acid (DNA) topoisomerases are essential for removing the supercoiling that normally builds up ahead of replication forks. The camptothecin (CPT) Top1 (topoisomerase I) inhibitors exert their anticancer activity by reversibly trapping Top1–DNA cleavage complexes (Top1cc’s) and induci...

Descripción completa

Detalles Bibliográficos
Autores principales:	Regairaz, Marie, Zhang, Yong-Wei, Fu, Haiqing, Agama, Keli K., Tata, Nalini, Agrawal, Surbhi, Aladjem, Mirit I., Pommier, Yves
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2011
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3257568/ https://www.ncbi.nlm.nih.gov/pubmed/22123861 http://dx.doi.org/10.1083/jcb.201104003

Ejemplares similares

The DNA repair endonuclease Mus81 facilitates fast DNA replication in the absence of exogenous damage
por: Fu, Haiqing, et al.
Publicado: (2015)

Poly(ADP-ribose) polymerase and XPF–ERCC1 participate in distinct pathways for the repair of topoisomerase I-induced DNA damage in mammalian cells
por: Zhang, Yong-Wei, et al.
Publicado: (2011)

Replication fork stalling in WRN-deficient cells is overcome by prompt activation of a MUS81-dependent pathway
por: Franchitto, Annapaola, et al.
Publicado: (2008)

MUS81-EME2 Promotes Replication Fork Restart
por: Pepe, Alessandra, et al.
Publicado: (2014)

Exploring DNA Topoisomerase I Ligand Space in Search of Novel Anticancer Agents
por: Drwal, Malgorzata N., et al.
Publicado: (2011)

Acute MUS81 depletion leads to replication fork slowing and a constitutive DNA damage response
por: Xing, Meichun, et al.
Publicado: (2015)

DNA replication profiling by molecular combing on single DNA fibers
por: Fu, Haiqing, et al.
Publicado: (2022)

Design, Synthesis, and Biological Evaluation of O-2-Modified Indenoisoquinolines as Dual Topoisomerase I–Tyrosyl-DNA Phosphodiesterase I Inhibitors
por: Lv, Peng-Cheng, et al.
Publicado: (2014)

The modulation of topoisomerase I-mediated DNA cleavage and the induction of DNA–topoisomerase I crosslinks by crotonaldehyde-derived DNA adducts
por: Dexheimer, Thomas S., et al.
Publicado: (2008)

A winged helix domain in human MUS81 binds DNA and modulates the endonuclease activity of MUS81 complexes
por: Fadden, Andrew J., et al.
Publicado: (2013)

A stalled fork stalls recombination
por: Tuma, Rabiya S.
Publicado: (2005)

PTEN Regulates DNA Replication Progression and Stalled Fork Recovery
por: He, Jinxue, et al.
Publicado: (2015)

Advances in understanding DNA processing and protection at stalled replication forks
por: Rickman, Kimberly, et al.
Publicado: (2019)

From Antarctica to cancer research: a novel human DNA topoisomerase 1B inhibitor from Antarctic sponge Dendrilla antarctica
por: Ottaviani, Alessio, et al.
Publicado: (2022)

Phosphorylated RPA recruits PALB2 to stalled DNA replication forks to facilitate fork recovery
por: Murphy, Anar K., et al.
Publicado: (2014)

PARylation prevents the proteasomal degradation of topoisomerase I DNA-protein crosslinks and induces their deubiquitylation
por: Sun, Yilun, et al.
Publicado: (2021)

BLM SUMOylation regulates ssDNA accumulation at stalled replication forks
por: Ouyang, Karen J., et al.
Publicado: (2013)

Forks on the Run: Can the Stalling of DNA Replication Promote Epigenetic Changes?
por: Rowlands, Hollie, et al.
Publicado: (2017)

Optimization of the Lactam Side Chain of 7-Azaindenoisoquinoline Topoisomerase I Inhibitors and Mechanism of Action Studies in Cancer Cells
por: Kiselev, Evgeny, et al.
Publicado: (2014)

The Mus81-Mms4 structure-selective endonuclease requires nicked DNA junctions to undergo conformational changes and bend its DNA substrates for cleavage
por: Mukherjee, Sucheta, et al.
Publicado: (2014)

DNA and RNA Cleavage Complexes and Repair Pathway for TOP3B RNA- and DNA-Protein Crosslinks
por: Saha, Sourav, et al.
Publicado: (2020)

MRE11 and EXO1 nucleases degrade reversed forks and elicit MUS81-dependent fork rescue in BRCA2-deficient cells
por: Lemaçon, Delphine, et al.
Publicado: (2017)

A model of DNA damage response activation at stalled replication forks by SPRTN
por: Bruhn, Christopher, et al.
Publicado: (2019)

Mechanistic insight into AP-endonuclease 1 cleavage of abasic sites at stalled replication fork mimics
por: Hoitsma, Nicole M, et al.
Publicado: (2023)

Human Pif1 helicase unwinds synthetic DNA structures resembling stalled DNA replication forks
por: George, Tresa, et al.
Publicado: (2009)

DNA polymerase κ-dependent DNA synthesis at stalled replication forks is important for CHK1 activation
por: Bétous, Rémy, et al.
Publicado: (2013)

DNA Helicase-SSB Interactions Critical to the Regression and Restart of Stalled DNA Replication Forks in Escherichia coli
por: Bianco, Piero R.
Publicado: (2020)

A junction branch point adjacent to a DNA backbone nick directs substrate cleavage by Saccharomyces cerevisiae Mus81-Mms4
por: Ehmsen, Kirk Tevebaugh, et al.
Publicado: (2009)

A fresh start for stalled forks
por: Leslie, Mitch
Publicado: (2015)

Replication fork stalling by bulky DNA damage: localization at active origins and checkpoint modulation
por: Minca, Eugen C., et al.
Publicado: (2011)

Replication fork slowing and stalling are distinct, checkpoint-independent consequences of replicating damaged DNA
por: Iyer, Divya Ramalingam, et al.
Publicado: (2017)

The antitumor activity of CYB-L10, a human topoisomerase IB catalytic inhibitor
por: Yu, Qian, et al.
Publicado: (2019)

ATAD5 regulates the lifespan of DNA replication factories by modulating PCNA level on the chromatin
por: Lee, Kyoo-young, et al.
Publicado: (2013)

RecG and UvsW catalyse robust DNA rewinding critical for stalled DNA replication fork rescue
por: Manosas, Maria, et al.
Publicado: (2013)

Mammalian RAD51 paralogs protect nascent DNA at stalled forks and mediate replication restart
por: Somyajit, Kumar, et al.
Publicado: (2015)

Limiting homologous recombination at stalled replication forks is essential for cell viability: DNA2 to the rescue
por: Appanah, Rowin, et al.
Publicado: (2020)

Mammalian RAD51 paralogs protect nascent DNA at stalled forks and mediate replication restart
por: Somyajit, Kumar, et al.
Publicado: (2020)

Innate immunity mediator STING modulates nascent DNA metabolism at stalled forks in human cells
por: Lazarchuk, Pavlo, et al.
Publicado: (2023)

Saccharomyces cerevisiae Mus81-Mms4 is a catalytic, DNA structure-selective endonuclease
por: Ehmsen, Kirk Tevebaugh, et al.
Publicado: (2008)

MUS81 Participates in the Progression of Serous Ovarian Cancer Associated With Dysfunctional DNA Repair System
por: Lu, Renquan, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_l5nipi000bro9tcthlibouqoa1