Quantitative model of R-loop forming structures reveals a novel level of RNA–DNA interactome complexity

R-loop is the structure co-transcriptionally formed between nascent RNA transcript and DNA template, leaving the non-transcribed DNA strand unpaired. This structure can be involved in the hyper-mutation and dsDNA breaks in mammalian immunoglobulin (Ig) genes, oncogenes and neurodegenerative disease...

Descripción completa

Detalles Bibliográficos
Autores principales: Wongsurawat, Thidathip, Jenjaroenpun, Piroon, Kwoh, Chee Keong, Kuznetsov, Vladimir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2012
Materias:
Methods Online
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3258121/
https://www.ncbi.nlm.nih.gov/pubmed/22121227
http://dx.doi.org/10.1093/nar/gkr1075

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3258121/
https://www.ncbi.nlm.nih.gov/pubmed/22121227
http://dx.doi.org/10.1093/nar/gkr1075

Ejemplares similares