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Quantitative model of R-loop forming structures reveals a novel level of RNA–DNA interactome complexity

R-loop is the structure co-transcriptionally formed between nascent RNA transcript and DNA template, leaving the non-transcribed DNA strand unpaired. This structure can be involved in the hyper-mutation and dsDNA breaks in mammalian immunoglobulin (Ig) genes, oncogenes and neurodegenerative disease...

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Detalles Bibliográficos
Autores principales:	Wongsurawat, Thidathip, Jenjaroenpun, Piroon, Kwoh, Chee Keong, Kuznetsov, Vladimir
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2012
Materias:	Methods Online
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3258121/ https://www.ncbi.nlm.nih.gov/pubmed/22121227 http://dx.doi.org/10.1093/nar/gkr1075

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