Human telomerase acts as a hTR-independent reverse transcriptase in mitochondria

Human telomerase reverse transcriptase (hTERT) is localized to mitochondria, as well as the nucleus, but details about its biology and function in the organelle remain largely unknown. Here we show, using multiple approaches, that mammalian TERT is mitochondrial, co-purifying with mitochondrial nucl...

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Detalles Bibliográficos
Autores principales: Sharma, Nilesh K., Reyes, Aurelio, Green, Paula, Caron, Matthieu J., Bonini, Marcelo G., Gordon, Donna M., Holt, Ian J., Santos, Janine Hertzog
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2012
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3258147/
https://www.ncbi.nlm.nih.gov/pubmed/21937513
http://dx.doi.org/10.1093/nar/gkr758

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3258147/
https://www.ncbi.nlm.nih.gov/pubmed/21937513
http://dx.doi.org/10.1093/nar/gkr758

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