Creating highly specific nucleases by fusion of active restriction endonucleases and catalytically inactive homing endonucleases

Zinc-finger nucleases and TALE nucleases are produced by combining a specific DNA-binding module and a non-specific DNA-cleavage module, resulting in nucleases able to cleave DNA at a unique sequence. Here a new approach for creating highly specific nucleases was pursued by fusing a catalytically in...

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Detalles Bibliográficos
Autores principales: Fonfara, Ines, Curth, Ute, Pingoud, Alfred, Wende, Wolfgang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2012
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3258161/
https://www.ncbi.nlm.nih.gov/pubmed/21965534
http://dx.doi.org/10.1093/nar/gkr788

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3258161/
https://www.ncbi.nlm.nih.gov/pubmed/21965534
http://dx.doi.org/10.1093/nar/gkr788

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