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PLCζ causes Ca(2+) oscillations in mouse eggs by targeting intracellular and not plasma membrane PI(4,5)P(2)
Sperm-specific phospholipase C ζ (PLCζ) activates embryo development by triggering intracellular Ca(2+) oscillations in mammalian eggs indistinguishable from those at fertilization. Somatic PLC isozymes generate inositol 1,4,5-trisphophate–mediated Ca(2+) release by hydrolyzing phosphatidylinositol...
Autores principales: | Yu, Yuansong, Nomikos, Michail, Theodoridou, Maria, Nounesis, George, Lai, F. Anthony, Swann, Karl |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The American Society for Cell Biology
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3258180/ https://www.ncbi.nlm.nih.gov/pubmed/22114355 http://dx.doi.org/10.1091/mbc.E11-08-0687 |
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