The association of DNA damage response and nucleotide level modulation with the antibacterial mechanism of the anti-folate drug Trimethoprim

BACKGROUND: Trimethoprim is a widely prescribed antibiotic for a variety of bacterial infections. It belongs to a class of anti-metabolites - antifolates - which includes drugs used against malarial parasites and in cancer therapy. However, spread of bacterial resistance to the drug has severely ham...

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Detalles Bibliográficos
Autores principales: Sangurdekar, Dipen P, Zhang, Zhigang, Khodursky, Arkady B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3258297/
https://www.ncbi.nlm.nih.gov/pubmed/22122981
http://dx.doi.org/10.1186/1471-2164-12-583

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3258297/
https://www.ncbi.nlm.nih.gov/pubmed/22122981
http://dx.doi.org/10.1186/1471-2164-12-583

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