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The association of DNA damage response and nucleotide level modulation with the antibacterial mechanism of the anti-folate drug Trimethoprim
BACKGROUND: Trimethoprim is a widely prescribed antibiotic for a variety of bacterial infections. It belongs to a class of anti-metabolites - antifolates - which includes drugs used against malarial parasites and in cancer therapy. However, spread of bacterial resistance to the drug has severely ham...
Autores principales: | Sangurdekar, Dipen P, Zhang, Zhigang, Khodursky, Arkady B |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3258297/ https://www.ncbi.nlm.nih.gov/pubmed/22122981 http://dx.doi.org/10.1186/1471-2164-12-583 |
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