Carboxylic acid derivatives of histone deacetylase inhibitors induce full length SMN2 transcripts: a promising target for spinal muscular atrophy therapeutics

INTRODUCTION: Proximal spinal muscular atrophy (SMA) is a common autosomal recessively inherited neuromuscular disorder. It is caused by homozygous absence of the survival motor neuron 1 (SMN1) gene. SMN2, which modulates the severity of the disease, represents a major target for therapy. The aim of...

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Detalles Bibliográficos
Autores principales: Dayangac-Erden, Didem, Bora-Tatar, Gamze, Dalkara, Sevim, Demir, Ayhan S., Erdem-Yurter, Hayat
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Termedia Publishing House 2011
Materias:
Basic Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3258711/
https://www.ncbi.nlm.nih.gov/pubmed/22291761
http://dx.doi.org/10.5114/aoms.2011.22072

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3258711/
https://www.ncbi.nlm.nih.gov/pubmed/22291761
http://dx.doi.org/10.5114/aoms.2011.22072

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