Leucine-rich repeat kinase 2 regulates autophagy through a calcium-dependent pathway involving NAADP

Mutations in the leucine-rich repeat kinase-2 (LRRK2) gene cause late-onset Parkinson’s disease, but its physiological function has remained largely unknown. Here we report that LRRK2 activates a calcium-dependent protein kinase kinase-β (CaMKK-β)/adenosine monophosphate (AMP)-activated protein kina...

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Detalles Bibliográficos
Autores principales: Gómez-Suaga, Patricia, Luzón-Toro, Berta, Churamani, Dev, Zhang, Ling, Bloor-Young, Duncan, Patel, Sandip, Woodman, Philip G., Churchill, Grant C., Hilfiker, Sabine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2012
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3259011/
https://www.ncbi.nlm.nih.gov/pubmed/22012985
http://dx.doi.org/10.1093/hmg/ddr481

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3259011/
https://www.ncbi.nlm.nih.gov/pubmed/22012985
http://dx.doi.org/10.1093/hmg/ddr481

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