Interleukin-4 in the Generation of the AERD Phenotype: Implications for Molecular Mechanisms Driving Therapeutic Benefit of Aspirin Desensitization

Aspirin-exacerbated respiratory disease (AERD) is explained in part by over-expression of 5-lipoxygenase, leukotriene C4 synthase (LTC(4)S) and the cysteinyl leukotriene (CysLT) receptors (CysLT1 and 2), resulting in constitutive over-production of CysLTs and the hyperresponsiveness to CysLTs that o...

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Detalles Bibliográficos
Autores principales: Steinke, John W., Payne, Spencer C., Borish, Larry
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3259477/
https://www.ncbi.nlm.nih.gov/pubmed/22262978
http://dx.doi.org/10.1155/2012/182090

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3259477/
https://www.ncbi.nlm.nih.gov/pubmed/22262978
http://dx.doi.org/10.1155/2012/182090

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