Dissociation of ERK signalling inhibition from the anti-amyloidogenic action of synthetic ceramide analogues

Inhibition of GSL (glycosphingolipid) synthesis reduces Aβ (amyloid β-peptide) production in vitro. Previous studies indicate that GCS (glucosylceramide synthase) inhibitors modulate phosphorylation of ERK1/2 (extracellular-signal-regulated kinase 1/2) and that the ERK pathway may regulate some aspe...

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Detalles Bibliográficos
Autores principales: Li, Hongyun, Evin, Genevieve, Hill, Andrew F., Hung, Ya Hui, Bush, Ashley I., Garner, Brett
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3259697/
https://www.ncbi.nlm.nih.gov/pubmed/22103431
http://dx.doi.org/10.1042/CS20110257

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3259697/
https://www.ncbi.nlm.nih.gov/pubmed/22103431
http://dx.doi.org/10.1042/CS20110257

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