FRET-Based Detection of M(1) Muscarinic Acetylcholine Receptor Activation by Orthosteric and Allosteric Agonists

BACKGROUND AND OBJECTIVE: Muscarinic acetylcholine receptors (mAChRs) are 7-transmembrane, G protein-coupled receptors that regulate a variety of physiological processes and represent potentially important targets for therapeutic intervention. mAChRs can be stimulated by full and partial orthosteric...

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Detalles Bibliográficos
Autores principales: Markovic, Danijela, Holdich, Jonathan, Al-Sabah, Suleiman, Mistry, Rajendra, Krasel, Cornelius, Mahaut-Smith, Martyn P., Challiss, R. A. John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3260180/
https://www.ncbi.nlm.nih.gov/pubmed/22272263
http://dx.doi.org/10.1371/journal.pone.0029946

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3260180/
https://www.ncbi.nlm.nih.gov/pubmed/22272263
http://dx.doi.org/10.1371/journal.pone.0029946

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