Kinesin Light Chain 1 Suppression Impairs Human Embryonic Stem Cell Neural Differentiation and Amyloid Precursor Protein Metabolism

The etiology of sporadic Alzheimer disease (AD) is largely unknown, although evidence implicates the pathological hallmark molecules amyloid beta (Aβ) and phosphorylated Tau. Work in animal models suggests that altered axonal transport caused by Kinesin-1 dysfunction perturbs levels of both Aβ and p...

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Detalles Bibliográficos
Autores principales: Killian, Rhiannon L., Flippin, Jessica D., Herrera, Cheryl M., Almenar-Queralt, Angels, Goldstein, Lawrence S. B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3260181/
https://www.ncbi.nlm.nih.gov/pubmed/22272245
http://dx.doi.org/10.1371/journal.pone.0029755

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3260181/
https://www.ncbi.nlm.nih.gov/pubmed/22272245
http://dx.doi.org/10.1371/journal.pone.0029755

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