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HERC6 Is the Main E3 Ligase for Global ISG15 Conjugation in Mouse Cells
Type I interferon (IFN) stimulates expression and conjugation of the ubiquitin-like modifier IFN-stimulated gene 15 (ISG15), thereby restricting replication of a wide variety of viruses. Conjugation of ISG15 is critical for its antiviral activity in mice. HECT domain and RCC1-like domain containing...
Autores principales: | Oudshoorn, Diede, van Boheemen, Sander, Sánchez-Aparicio, Maria Teresa, Rajsbaum, Ricardo, García-Sastre, Adolfo, Versteeg, Gijs A. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3260183/ https://www.ncbi.nlm.nih.gov/pubmed/22272257 http://dx.doi.org/10.1371/journal.pone.0029870 |
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