Cardiac-Specific Expression of the Tetracycline Transactivator Confers Increased Heart Function and Survival Following Ischemia Reperfusion Injury

Mice expressing the tetracycline transactivator (tTA) transcription factor driven by the rat α-myosin heavy chain promoter (α-MHC-tTA) are widely used to dissect the molecular mechanisms involved in cardiac development and disease. However, these α-MHC-tTA mice exhibit a gain-of-function phenotype c...

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Detalles Bibliográficos
Autores principales: Elsherif, Laila, Wang, Xuerong, Grachoff, Milana, Wolska, Beata M., Geenen, David L., O'Bryan, John P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3260203/
https://www.ncbi.nlm.nih.gov/pubmed/22272284
http://dx.doi.org/10.1371/journal.pone.0030129

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3260203/
https://www.ncbi.nlm.nih.gov/pubmed/22272284
http://dx.doi.org/10.1371/journal.pone.0030129

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