Site-Directed Mutations and the Polymorphic Variant Ala160Thr in the Human Thromboxane Receptor Uncover a Structural Role for Transmembrane Helix 4

The human thromboxane A2 receptor (TP), belongs to the prostanoid subfamily of Class A GPCRs and mediates vasoconstriction and promotes thrombosis on binding to thromboxane (TXA2). In Class A GPCRs, transmembrane (TM) helix 4 appears to be a hot spot for non-synonymous single nucleotide polymorphic...

Descripción completa

Detalles Bibliográficos
Autores principales: Chakraborty, Raja, Pydi, Sai Prasad, Gleim, Scott, Dakshinamurti, Shyamala, Hwa, John, Chelikani, Prashen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3260207/
https://www.ncbi.nlm.nih.gov/pubmed/22272267
http://dx.doi.org/10.1371/journal.pone.0029996

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3260207/
https://www.ncbi.nlm.nih.gov/pubmed/22272267
http://dx.doi.org/10.1371/journal.pone.0029996

Ejemplares similares