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Site-Directed Mutations and the Polymorphic Variant Ala160Thr in the Human Thromboxane Receptor Uncover a Structural Role for Transmembrane Helix 4
The human thromboxane A2 receptor (TP), belongs to the prostanoid subfamily of Class A GPCRs and mediates vasoconstriction and promotes thrombosis on binding to thromboxane (TXA2). In Class A GPCRs, transmembrane (TM) helix 4 appears to be a hot spot for non-synonymous single nucleotide polymorphic...
Autores principales: | Chakraborty, Raja, Pydi, Sai Prasad, Gleim, Scott, Dakshinamurti, Shyamala, Hwa, John, Chelikani, Prashen |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3260207/ https://www.ncbi.nlm.nih.gov/pubmed/22272267 http://dx.doi.org/10.1371/journal.pone.0029996 |
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