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Antifibrotic effects of curcumin are associated with overexpression of cathepsins K and L in bleomycin treated mice and human fibroblasts

BACKGROUND: Lung fibrosis is characterized by fibroblast proliferation and the deposition of collagens. Curcumin, a polyphenol antioxidant from the spice tumeric, has been shown to effectively counteract fibroblast proliferation and reducing inflammation and fibrotic progression in animal models of...

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Detalles Bibliográficos
Autores principales: Zhang, Dongwei, Huang, Chuangfang, Yang, Changfu, Liu, Renzuo J, Wang, Jifeng, Niu, Jianzhao, Brömme, Dieter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3260240/
https://www.ncbi.nlm.nih.gov/pubmed/22126332
http://dx.doi.org/10.1186/1465-9921-12-154