A mitochondrial-targeted cyclosporin A with high binding affinity for cyclophilin D yields improved cytoprotection of cardiomyocytes

Mitochondrial CyP-D (cyclophilin-D) catalyses formation of the PT (permeability transition) pore, a key lesion in the pathogenesis of I/R (ischaemia/reperfusion) injury. There is evidence [Malouitre, Dube, Selwood and Crompton (2010) Biochem. J. 425, 137–148] that cytoprotection by the CyP inhibitor...

Descripción completa

Detalles Bibliográficos
Autores principales: Dube, Henry, Selwood, David, Malouitre, Sylvanie, Capano, Michela, Simone, Michela I., Crompton, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3260541/
https://www.ncbi.nlm.nih.gov/pubmed/22035570
http://dx.doi.org/10.1042/BJ20111301

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3260541/
https://www.ncbi.nlm.nih.gov/pubmed/22035570
http://dx.doi.org/10.1042/BJ20111301

Ejemplares similares