Proteotoxic stress targeted therapy (PSTT): induction of protein misfolding enhances the antitumor effect of the proteasome inhibitor bortezomib

Proteotoxic stress (PS) is generated in cells under a variety of conditions involving accumulation of misfolded proteins. To avoid the toxicity of unmitigated PS, cells activate the heat shock response (HSR). HSR involves upregulation of factors such as ubiquitin and the non-housekeeping chaperone H...

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Detalles Bibliográficos
Autores principales: Neznanov, Nickolay, Komarov, Andrei P., Neznanova, Lubov, Stanhope-Baker, Patricia, Gudkov, Andrei V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2011
Materias:
Research Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3260823/
https://www.ncbi.nlm.nih.gov/pubmed/21444945

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3260823/
https://www.ncbi.nlm.nih.gov/pubmed/21444945

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