Largazole and Its Derivatives Selectively Inhibit Ubiquitin Activating Enzyme (E1)

Protein ubiquitination plays an important role in the regulation of almost every aspect of eukaryotic cellular function; therefore, its destabilization is often observed in most human diseases and cancers. Consequently, developing inhibitors of the ubiquitination system for the treatment of cancer h...

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Detalles Bibliográficos
Autores principales: Ungermannova, Dana, Parker, Seth J., Nasveschuk, Christopher G., Wang, Wei, Quade, Bettina, Zhang, Gan, Kuchta, Robert D., Phillips, Andrew J., Liu, Xuedong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3261141/
https://www.ncbi.nlm.nih.gov/pubmed/22279528
http://dx.doi.org/10.1371/journal.pone.0029208

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3261141/
https://www.ncbi.nlm.nih.gov/pubmed/22279528
http://dx.doi.org/10.1371/journal.pone.0029208

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