Cargando…

Largazole and Its Derivatives Selectively Inhibit Ubiquitin Activating Enzyme (E1)

Protein ubiquitination plays an important role in the regulation of almost every aspect of eukaryotic cellular function; therefore, its destabilization is often observed in most human diseases and cancers. Consequently, developing inhibitors of the ubiquitination system for the treatment of cancer h...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ungermannova, Dana, Parker, Seth J., Nasveschuk, Christopher G., Wang, Wei, Quade, Bettina, Zhang, Gan, Kuchta, Robert D., Phillips, Andrew J., Liu, Xuedong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3261141/ https://www.ncbi.nlm.nih.gov/pubmed/22279528 http://dx.doi.org/10.1371/journal.pone.0029208

Ejemplares similares

Largazole Pharmacokinetics in Rats by LC-MS/MS
por: Yu, Mingming, et al.
Publicado: (2014)

Largazole Inhibits Ocular Angiogenesis by Modulating the Expression of VEGFR2 and p21
por: Qiu, Beiying, et al.
Publicado: (2021)

Unexpected Enhancement of HDACs Inhibition by MeS Substitution at C-2 Position of Fluoro Largazole
por: Zhang, Bingbing, et al.
Publicado: (2020)

Synthetic Routes and Biological Evaluation of Largazole and Its Analogues as Potent Histone Deacetylase Inhibitors
por: Li, Shang, et al.
Publicado: (2011)

Synthesis and Preliminary Biological Evaluation of Two Fluoroolefin Analogs of Largazole Inspired by the Structural Similarity of the Side Chain Unit in Psammaplin A
por: Zhang, Bingbing, et al.
Publicado: (2019)

Ubiquitination independent of E1 and E2 enzymes by bacterial effectors
por: Qiu, Jiazhang, et al.
Publicado: (2016)

Selective Recruitment of an E2∼Ubiquitin Complex by an E3 Ubiquitin Ligase
por: Spratt, Donald E., et al.
Publicado: (2012)

E2 enzyme inhibition by stabilization of a low affinity interface with ubiquitin
por: Huang, Hao, et al.
Publicado: (2013)

Mutations of Rad6 E2 ubiquitin-conjugating enzymes at alanine-126 in helix-3 affect ubiquitination activity and decrease enzyme stability
por: Shukla, Prakash K., et al.
Publicado: (2022)

Ubiquitin-Mimicking Peptides Transfer Differentiates by E1 and E2 Enzymes
por: Jin, Bo, et al.
Publicado: (2018)

Wheat germ-based protein libraries for the functional characterisation of the Arabidopsis E2 ubiquitin conjugating enzymes and the RING-type E3 ubiquitin ligase enzymes
por: Ramadan, Abdelaziz, et al.
Publicado: (2015)

From seeds to trees: how E2 enzymes grow ubiquitin chains
por: Middleton, Adam J., et al.
Publicado: (2023)

E2 ubiquitin conjugating enzymes regulate the deubiquitinating activity of OTUB1
por: Wiener, Reuven, et al.
Publicado: (2013)

Ubiquitin-activating enzyme, E1, is associated with maturation of autophagic vacuoles
Publicado: (1992)

Structural insights into E1 recognition and the ubiquitin-conjugating activity of the E2 enzyme Cdc34
por: Williams, Katelyn M., et al.
Publicado: (2019)

Ubiquitin-Conjugating Enzyme E2 E Inhibits the Accumulation of Rice Stripe Virus in Laodelphax striatellus (Fallén)
por: Li, Yao, et al.
Publicado: (2020)

The Ubiquitin Conjugating Enzyme: An Important Ubiquitin Transfer Platform in Ubiquitin-Proteasome System
por: Liu, Weigang, et al.
Publicado: (2020)

Protein ubiquitination and formation of polyubiquitin chains without ATP, E1 and E2 enzymes
por: Park, Sungjin, et al.
Publicado: (2015)

Ubiquitin-Conjugating Enzymes in Cancer
por: Bui, Quyen Thu, et al.
Publicado: (2021)

Functional and phylogenetic analysis of the ubiquitylation system in Caenorhabditis elegans: ubiquitin-conjugating enzymes, ubiquitin-activating enzymes, and ubiquitin-like proteins
por: Jones, Donald, et al.
Publicado: (2002)

Expression of ubiquitin-conjugating enzyme E2T in colorectal cancers and clinical implications
por: Wu, Xiangtian, et al.
Publicado: (2020)

Auranofin targets UBA1 and enhances UBA1 activity by facilitating ubiquitin trans-thioesterification to E2 ubiquitin-conjugating enzymes
por: Yan, Wenjing, et al.
Publicado: (2023)

Functional conservation and divergence of the helix‐turn‐helix motif of E2 ubiquitin‐conjugating enzymes
por: Welsh, Kaeli A, et al.
Publicado: (2021)

Loss of the ubiquitin conjugating enzyme UBE2E3 induces cellular senescence
por: Plafker, Kendra S., et al.
Publicado: (2018)

Genome-wide identification and expression analysis of E2 ubiquitin-conjugating enzymes in tomato
por: Sharma, Bhaskar, et al.
Publicado: (2017)

Targeting CDC34 E2 ubiquitin conjugating enzyme for lung cancer therapy
por: Zhang, Shizhen, et al.
Publicado: (2020)

Ubiquitin enzymes in the regulation of immune responses
por: Ebner, Petra, et al.
Publicado: (2017)

Ubiquitin-modifying enzymes in Huntington’s disease
por: Sap, Karen A., et al.
Publicado: (2023)

African swine fever virus encodes for an E2-ubiquitin conjugating enzyme that is mono- and di-ubiquitinated and required for viral replication cycle
por: Freitas, Ferdinando B., et al.
Publicado: (2018)

Orthogonal ubiquitin transfer identifies ubiquitination substrates under differential control by the two ubiquitin activating enzymes
por: Liu, Xianpeng, et al.
Publicado: (2017)

Characterization of ubiquitin and ubiquitin-like-protein isopeptidase activities
por: Nicholson, Benjamin, et al.
Publicado: (2008)

Inhibition of the Ubiquitin-Activating Enzyme UBA1 Suppresses Diet-Induced Atherosclerosis in Apolipoprotein E-Knockout Mice
por: Liao, Jiawei, et al.
Publicado: (2020)

Interactions between the quality control ubiquitin ligase CHIP and ubiquitin conjugating enzymes
por: Xu, Zhen, et al.
Publicado: (2008)

Changes in the ratio of free NEDD8 to ubiquitin triggers NEDDylation by ubiquitin enzymes
por: Hjerpe, Roland, et al.
Publicado: (2012)

What Was the Set of Ubiquitin and Ubiquitin-Like Conjugating Enzymes in the Eukaryote Common Ancestor?
por: Michelle, Caroline, et al.
Publicado: (2009)

Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
por: Rut, Wioletta, et al.
Publicado: (2020)

Mutation in E1, the Ubiquitin Activating Enzyme, Reduces Drosophila Lifespan and Results in Motor Impairment
por: Liu, Hsiu-Yu, et al.
Publicado: (2013)

The Molecular Basis of Ubiquitin-Conjugating Enzymes (E2s) as a Potential Target for Cancer Therapy
por: Du, Xiaodi, et al.
Publicado: (2021)

A Bifunctional Enzyme of Legionella that Distinctly Regulates Phosphoribosyl Ubiquitination of the SidE Family Effectors
por: Jiao, Jun, et al.
Publicado: (2022)

Overexpression of Ubiquitin-Conjugating Enzyme E2C Is Associated with Worsened Prognosis in Prostate Cancer
por: Wu, Xiaobo, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_nehnvngianj46chql71k8goa0t