The Chemotactic Defect in Wiskott-Aldrich Syndrome Macrophages Is Due to the Reduced Persistence of Directional Protrusions

Wiskott-Aldrich syndrome protein (WASp) is an actin nucleation promoting factor that is required for macrophages to directionally migrate towards various chemoattractants. The chemotaxis defect of WASp-deficient cells and its activation by Cdc42 in vivo suggest that WASp plays a role in directional...

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Detalles Bibliográficos
Autores principales: Ishihara, Dan, Dovas, Athanassios, Park, Haein, Isaac, Beth M., Cox, Dianne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3261183/
https://www.ncbi.nlm.nih.gov/pubmed/22279563
http://dx.doi.org/10.1371/journal.pone.0030033

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3261183/
https://www.ncbi.nlm.nih.gov/pubmed/22279563
http://dx.doi.org/10.1371/journal.pone.0030033

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