Absence of the DNA repair enzyme human 8-oxoguanine glycosylase is associated with an aggressive breast cancer phenotype

BACKGROUND: 8-Oxo-7,8-dihydro-2′-deoxyguanosine (8-oxodG) is the most abundant marker of DNA damage and it reflects oxidative stress. Human 8-oxoguanine glycosylase (hOGG1) is a DNA-repair enzyme that participates in 8-oxodG removal. METHODS: hOGG1 protein expression was immunohistochemically studie...

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Detalles Bibliográficos
Autores principales: Karihtala, P, Kauppila, S, Puistola, U, Jukkola-Vuorinen, A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2012
Materias:
Molecular Diagnostics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3261678/
https://www.ncbi.nlm.nih.gov/pubmed/22108520
http://dx.doi.org/10.1038/bjc.2011.518

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3261678/
https://www.ncbi.nlm.nih.gov/pubmed/22108520
http://dx.doi.org/10.1038/bjc.2011.518

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