Benzene Metabolite 1,2,4-Benzenetriol Induces Halogenated DNA and Tyrosines Representing Halogenative Stress in the HL-60 Human Myeloid Cell Line

Background: Although benzene is known to be myelotoxic and to cause myeloid leukemia in humans, the mechanism has not been elucidated. Objectives: We focused on 1,2,4-benzenetriol (BT), a benzene metabolite that generates reactive oxygen species (ROS) by autoxidation, to investigate the toxicity of...

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Detalles Bibliográficos
Autores principales: Nishikawa, Takuro, Miyahara, Emiko, Horiuchi, Masahisa, Izumo, Kimiko, Okamoto, Yasuhiro, Kawai, Yoshichika, Kawano, Yoshifumi, Takeuchi, Toru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Institute of Environmental Health Sciences 2011
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3261936/
https://www.ncbi.nlm.nih.gov/pubmed/21859636
http://dx.doi.org/10.1289/ehp.1103437

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3261936/
https://www.ncbi.nlm.nih.gov/pubmed/21859636
http://dx.doi.org/10.1289/ehp.1103437

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