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Benzene Metabolite 1,2,4-Benzenetriol Induces Halogenated DNA and Tyrosines Representing Halogenative Stress in the HL-60 Human Myeloid Cell Line
Background: Although benzene is known to be myelotoxic and to cause myeloid leukemia in humans, the mechanism has not been elucidated. Objectives: We focused on 1,2,4-benzenetriol (BT), a benzene metabolite that generates reactive oxygen species (ROS) by autoxidation, to investigate the toxicity of...
Autores principales: | Nishikawa, Takuro, Miyahara, Emiko, Horiuchi, Masahisa, Izumo, Kimiko, Okamoto, Yasuhiro, Kawai, Yoshichika, Kawano, Yoshifumi, Takeuchi, Toru |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
National Institute of Environmental Health Sciences
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3261936/ https://www.ncbi.nlm.nih.gov/pubmed/21859636 http://dx.doi.org/10.1289/ehp.1103437 |
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