Oxysterols are allosteric activators of the oncoprotein Smoothened

Oxysterols are a class of endogenous signaling molecules that can activate the Hedgehog pathway, which plays critical roles in development, regeneration and cancer. However, it has been unclear how oxysterols influence Hedgehog signaling, including whether their effects are mediated through a protei...

Descripción completa

Detalles Bibliográficos
Autores principales: Nachtergaele, Sigrid, Mydock, Laurel K., Krishnan, Kathiresan, Rammohan, Jayan, Schlesinger, Paul H., Covey, Douglas F., Rohatgi, Rajat
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3262054/
https://www.ncbi.nlm.nih.gov/pubmed/22231273
http://dx.doi.org/10.1038/nchembio.765

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3262054/
https://www.ncbi.nlm.nih.gov/pubmed/22231273
http://dx.doi.org/10.1038/nchembio.765

Ejemplares similares