Chemical Informatics and Target Identification in a Zebrafish Phenotypic Screen

Target identification is a core challenge in chemical genetics. Here we use chemical similarity to predict computationally the targets of 586 compounds active in a zebrafish behavioral assay. Of 20 predictions tested, 11 had activities ranging from 1 to 10,000nM on the predicted targets. The role of...

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Detalles Bibliográficos
Autores principales: Laggner, Christian, Kokel, David, Setola, Vincent, Tolia, Alexandra, Lin, Henry, Irwin, John J., Keiser, Michael J., Cheung, Chung Yan J., Minor, Daniel L., Roth, Bryan L., Peterson, Randall T., Shoichet, Brian K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3262069/
https://www.ncbi.nlm.nih.gov/pubmed/22179068
http://dx.doi.org/10.1038/nchembio.732

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3262069/
https://www.ncbi.nlm.nih.gov/pubmed/22179068
http://dx.doi.org/10.1038/nchembio.732

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