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A Kras(G12D)-Driven Genetic Mouse Model of Pancreatic Cancer Requires Glypican-1 for Efficient Proliferation and Angiogenesis

Pancreatic ductal adenocarcinomas (PDACs) exhibit multiple molecular alterations and overexpress heparin binding growth factors (HBGFs) and glypican-1 (GPC1), a heparan sulfate proteoglycan that promotes efficient signaling by HBGFs. It is not known, however, whether GPC1 plays a role in genetic mou...

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Detalles Bibliográficos
Autores principales: Whipple, Chery A., Young, Alison L., Korc, Murray
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3262079/
https://www.ncbi.nlm.nih.gov/pubmed/21996748
http://dx.doi.org/10.1038/onc.2011.430