Adaptive up-regulation of FOXD3 and resistance to PLX4032/4720-induced cell death in mutant B-RAF melanoma cells

Melanoma cells driven by mutant B-RAF are highly resistant to chemotherapeutic treatments. Recent Phase 1 results with PLX4032/RG7204/Vemurafenib, which selectively inhibits B-RAF/MEK/ERK1/2 signaling in mutant B-RAF cells, has given encouragement to this struggling field. Nearly all patients in the...

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Detalles Bibliográficos
Autores principales: Basile, Kevin J., Abel, Ethan V., Aplin, Andrew E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3262107/
https://www.ncbi.nlm.nih.gov/pubmed/21996740
http://dx.doi.org/10.1038/onc.2011.424

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3262107/
https://www.ncbi.nlm.nih.gov/pubmed/21996740
http://dx.doi.org/10.1038/onc.2011.424

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