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The PI3K/Akt pathway mediates the expression of type I collagen induced by TGF-β2 in human retinal pigment epithelial cells

PURPOSE: Transforming growth factor (TGF)-β is a key mediator of proliferative vitreoretinopathy, but the cellular mechanisms by which TGF-β induces extracellular matrix protein (ECM) synthesis are not fully understood. This study examined whether the PI3K/Akt pathway is involved in TGF-β2-induced c...

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Detalles Bibliográficos
Autores principales:	Yokoyama, Katsuhiko, Kimoto, Kenichi, Itoh, Yuji, Nakatsuka, Kazuo, Matsuo, Noritaka, Yoshioka, Hidekatsu, Kubota, Toshiaki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer-Verlag 2011
Materias:	Basic Science
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3262137/ https://www.ncbi.nlm.nih.gov/pubmed/21858467 http://dx.doi.org/10.1007/s00417-011-1766-x

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