Structure–Activity Relationship for the First-in-Class Clinical Steroid Sulfatase Inhibitor Irosustat (STX64, BN83495)

Structure–activity relationship studies were conducted on Irosustat (STX64, BN83495), the first steroid sulfatase (STS) inhibitor to enter diverse clinical trials for patients with advanced hormone-dependent cancer. The size of its aliphatic ring was expanded; its sulfamate group was N,N-dimethylate...

Descripción completa

Detalles Bibliográficos
Autores principales: Woo, L W Lawrence, Ganeshapillai, Dharshini, Thomas, Mark P, Sutcliffe, Oliver B, Malini, Bindu, Mahon, Mary F, Purohit, Atul, Potter, Barry V L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: WILEY-VCH Verlag 2011
Materias:
Full Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3262147/
https://www.ncbi.nlm.nih.gov/pubmed/21990014
http://dx.doi.org/10.1002/cmdc.201100288

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3262147/
https://www.ncbi.nlm.nih.gov/pubmed/21990014
http://dx.doi.org/10.1002/cmdc.201100288

Ejemplares similares